Contraindicated (1)pentobarbital will lower the extent or outcome of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will decrease the extent or impact of midostaurin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Robust CYP3A4 inducers may well lessen midostaurin concentrat